In brief

A definitive conclusion about the dangers associated with human or animal exposure to a particular nanomaterial can currently be made upon complex and costly procedures including complete characterisation of nanomaterials with consequent careful and well-controlled in vivo experiments. To advance the nanotoxicity prediction, we use in vivo, in vitro and in silico research, combined with systems biology and statistical methods, to address main respiratory toxicity pathways for a representative set of nanomaterials, to identify the mechanistic key events of the pathways, and to relate them to interactions at the bio-nano interface.

Using this knowledge, economic and straightforward tests will be developed to assess the ability of nanomaterial to produce the pathway-relevant key events. This approach will allow us to group materials based on their nanotoxicity and identify properties of concern for new materials, as well as reduce the need for expensive nanotoxicity testing in the future.



Current project members

Selected publications