A definitive conclusion about the dangers associated with human or animal exposure to a particular nanomaterial can currently be made upon complex and costly procedures including complete characterisation of nanomaterials with consequent careful and well-controlled in vivo experiments. To advance the nanotoxicity prediction, we use in vivo, in vitro and in silico research, combined with systems biology and statistical methods, to address main respiratory toxicity pathways for a representative set of nanomaterials, to identify the mechanistic key events of the pathways, and to relate them to interactions at the bio-nano interface.
Using this knowledge, economic and straightforward tests will be developed to assess the ability of nanomaterial to produce the pathway-relevant key events. This approach will allow us to group materials based on their nanotoxicity and identify properties of concern for new materials, as well as reduce the need for expensive nanotoxicity testing in the future.
Current project members
Boštjan Kokot, Hana Kokot, Polona Umek, Katarina Petra van Midden, Stane Pajk, Maja Garvas, Christian Eggeling, Tilen Koklič, Iztok Urbančič, Janez Štrancar
Nanotoxicology, October 2021 (read more here)
Hana Kokot, Boštjan Kokot, Aleksandar Sebastijanović, Carola Voss, Rok Podlipec, Patrycja Zawilska, Trine Berthing, Carolina Ballester-López, Pernille Høgh Danielsen, Claudia Contini, Mikhail Ivanov, Ana Krišelj, Petra Čotar, Qiaoxia Zhou, Jessica Ponti, Vadim Zhernovkov, Matthew Schneemilch, Zahra Doumandji, Mojca Pušnik, Polona Umek, Stane Pajk, Olivier Joubert, Otmar Schmid, Iztok Urbančič, Martin Irmler, Johannes Beckers, Vladimir Lobaskin, Sabina Halappanavar, Nick Quirke, Alexander P. Lyubartsev, Ulla Vogel, Tilen Koklič, Tobias Stoeger, Janez Štrancar
Advanced Materials, October 2020 (read more here)
Tilen Koklic, Iztok Urbančič, Irena Zdovc, Majda Golob, Polona Umek, Zoran Arsov, Goran Dražić, Štefan Pintarič, Martin Dobeic, Janez Štrancar
PLoS ONE, July 2018 (read more here)
Iztok Urbančič, Maja Garvas, Boštjan Kokot, Hana Majaron, Polona Umek, Hilary Cassidy, Miha Škarabot, Falk Schneider, Silvia Galiani, Zoran Arsov, Tilen Koklic, David Matallanas, Miran Čeh, Igor Muševič, Christian Eggeling, and Janez Štrancar
Nano Letters, July 2018 (read more here)
Zoran Arsov, Iztok Urbančič, Maja Garvas, Daniele Biglino, Ajasja Ljubetič, Tilen Koklič, Janez Štrancar
Biomedical optics express, August 2011 (read more here)