Prediction of Chronic Inflammation for Inhaled Particles: the Impact of Material Cycling and Quarantining in the Lung Epithelium

Hana Kokot, Boštjan Kokot, Aleksandar Sebastijanović, Carola Voss, Rok Podlipec, Patrycja Zawilska, Trine Berthing, Carolina Ballester-López, Pernille Høgh Danielsen, Claudia Contini, Mikhail Ivanov, Ana Krišelj, Petra Čotar, Qiaoxia Zhou, Jessica Ponti, Vadim Zhernovkov, Matthew Schneemilch, Zahra Doumandji, Mojca Pušnik, Polona Umek, Stane Pajk, Olivier Joubert, Otmar Schmid, Iztok Urbančič, Martin Irmler, Johannes Beckers, Vladimir Lobaskin, Sabina Halappanavar, Nick Quirke, Alexander P. Lyubartsev, Ulla Vogel, Tilen Koklič, Tobias Stoeger, Janez Štrancar
Advanced Materials, October 2020; doi: 10.1002/adma.202003913 (read more here).

In brief

The prediction of diseases associated with nanomaterials is currently hampered by an incomplete understanding of the underlying mechanisms. Together with international collaborators, we discovered nanomaterial quarantining and counteracting nanomaterial cycling, which allowed us to incorporate these main modes of cellular response into a mechanistic model and predict in vivo inflammation solely on animal-free in vitro tests. The paper was published in the prestigious journal Advanced Materials and selected as the frontispiece of the journal issue.