Serendipitous discovery of nitrogen bridgehead fused pyridines: photophysical properties and live-cell imaging potential
Hana Kokot, Aljoša Bolje, Jakob Kljun, Andraž Bevk, Natalija Trunkelj, Lucija Peterlin Mašič, Janez Mravljak, Stane PajkJournal of Photochemistry and Photobiology A: Chemistry, July 2026; doi: 10.1016/j.jphotochem.2026.117068 (read more here).
In brief
We synthesized and characterized novel fluorescent probes that exhibit pH-sensitive fluorescence and Stokes shifts exceeding 100 nm in several cases. Their pronounced spectral responsiveness and fluorescence lifetime variations indicates their potential for use as environment-sensitive intracellular sensors. One of the novel probes (1) exhibited particularly favourable properties, including high photostability, low background fluorescence, minimal cytotoxicity and polarity sensitivity.
