Tilen Koklič


T: +386 1 477 3438

F: +386 1 477 3191

E: tilen.koklic@ijs.si

A: Jamova 39, SI-1000 Ljubljana, Slovenia

R: J108



Cell-material interaction (liposomes, nanoparticles)

Development of drug delivery systems

Modeling complex enzyme reactions in blood coagulation

Applied research of antimicrobial surfaces


Spectroscopies (spin labeling EPR, fluorescence (micro)spectroscopy, FRET, IR spectroscopy, UV-VIS)

Microscopies (confocal fluorescence microscopy, AFM)

Preparation of liposomes, cell culturing

Data modeling

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Curriculum Vitae


2012, 2013

Visiting scientist at University of North Carolina at Chapell Hill (USA)

2005 - 2007

Postdoctoral training at University of North Carolina at Chapell Hill (USA)


Visiting scientist at Max Delbrück center for molecular medicine (Berlin-Buch, Germany)


PhD in biophysics at University of Ljubljana (Slovenia)


BSc in biophysics at University of Ljubljana (Slovenia)


2010 -

Researcher at Centre of Excellence NAMASTE

2000 -

Researcher at "Jozef Stefan" Institute


2014 -

J3-6803(C): The roles of calcium and lipid membranes in survival of critically ill patients (Leader)

2012 - 2013

BI-US/13-14-040: USA-Slovenia bilateral cooperation fellowship (Leader)


2013 -

Teaching assistant at University of Ljubljana, Faculty of mathematics and physics
course: Physics practicum

2000 -

Teaching assistant at University of Ljubljana, Biotechnical Faculty
course: Molecular and functional biology

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Selected scientific papers

KOKLIČ, Tilen, MAJUMDER, Rinku, LENTZ, Barry R.
Ca2+ switches the effect of ps-containing membranes on factor Xa from activating to inhibiting: implications for initiation of blood coagulation.
Biochem. j., 2014, vol. 462, no. 3, p. 591-601, doi: 10.1042/BJ20140130.

KOKLIČ, Tilen.
Perifosine induced release of contents of trans cell-barrier transport efficient liposomes.
Chem. phys. lipids, 2014, vol. 183, p. 50-59, doi: 10.1016/j.chemphyslip.2014.05.006.

MAJUMDER, Rinku, KOKLIČ, Tilen, SENGUPTA, Tanusree, COLE, Daud, CHATTOPADHYAY, Rima, BISWAS, Subir, MONROE, Dougald McDougald, LENTZ, Barry R.
Soluble phosphatidylserine binds to two sites on human Factor IXa in a Ca2+ dependent fashion to specifically regulate structure and activity.
PloS one, 2014, vol. 9, no. 6, p. 100006-1-100006-10, doi: 10.1371/journal.pone.0100006 (pdf).

MAJUMDER, Rinku, KOKLIČ, Tilen, REZAIE, Agheleh, LENTZ, Barry R.
Phosphatidylserine-induced factor Xa dimerization and binding to factor Va are competing processes in solution.
Biochemistry, 2013, vol. 52, issue 1, p. 143-151, doi: 10.1021/bi301239z.

Lysolipid containing liposomes for transendothelial drug delivery.
BMC research notes, 2012, vol. 5, art. no. 139, doi: 10.1186/1756-0500-5-179.

Influence of cancerostatic perifosine on membrane fluidity of liposomes and different cell lines as measured by electron paramagnetic resonance.
Croat. med. j., 2012, vol. 53, no. 6, p. 558-567 doi: 10.3325/cmj.2012.53.558.

ARSOV, Zoran, URBANČIČ, Iztok, GARVAS, Maja, BIGLINO, Daniele, LJUBETIČ, Ajasja, KOKLIČ, Tilen, ŠTRANCAR, Janez.
Fluorescence microspectroscopy as a tool to study mechanism of nanoparticles delivery into living cancer cells.
Biomed. opt. express, 2011, vol. 2, no. 8, p. 2083-2095, doi: 10.1364/BOE.2.002083 (pdf).

HAQUE, Md. Emdadul, CHAKRABORTY, Hirak, KOKLIČ, Tilen, KOMATSU, Hiroaki, AXELSEN, Paul H., LENTZ, Barry R.
Hemagglutinin fusion peptide mutants in model membranes: structural properties, membrane physical properties, and peg-mediated fusion.
Biophys. j., 2011, vol. 101, no. 5, p. 1095-1104,

KOKLIČ, Tilen, ŠENTJURC, Marjeta, ZEISIG, Reiner.
Determination of the amount of micelles in alkylphospholipid liposome formulations with electron paramagnetic resonance method.
Journal of liposome research, 2011, vol. 21, issue 1, p. 1-8, doi: 10.3109/08982101003596133.

BATISTA, Urška, GARVAS, Maja, NEMEC, Marjanca, SCHARA, Milan Valter, VERANIČ, Peter, KOKLIČ, Tilen.
Effects of different detachment procedures on viability, nitroxide reduction kinetics, and plasma membrane heterogeneity of V-79 cells.
Cell Biol Int, 2010, letn. 34, št. 6, p. 663-668, doi: 10.1042/CBI20090276.

KOKLIČ, Tilen, MAJUMDER, Rinku, WEINREB, Gabriel E., LENTZ, Barry R.
Factor Xa binding to phosphatidylserine-containing membranes produces an inactive membrane-bound dimer.
Biophys. j., 2009, vol. 97, no. 8, p. 2232-2241.

KOKLIČ, Tilen, ZEISIG, Reiner, ŠENTJURC, Marjeta.
Interaction of alkylphospholipid liposomes with MT-3 breat-cancer cells depends critically on cholesterol concentration.
Biochim. biophys. acta, Biomembr., 2008, vol. 1778, no. 12, p. 2682-2689.

ŠTRANCAR, Janez, KOKLIČ, Tilen, ARSOV, Zoran, FILIPIČ, Bogdan, STOPAR, David, HEMMINGA, Marcus A.
Spin label EPR-based characterization of biosystem complexity.
J. chem. inf. mod., 2005, vol. 45, no. 2, p. 394-406.

KOKLIČ, Tilen, PIRŠ, Mateja, ZEISIG, Reiner, ABRAMOVIĆ, Zrinka, ŠENTJURC, Marjeta. Membrane switch hypothesis.
1., Cell density influences lateral domain structure of tumor cell membranes.
J. chem. inf. mod., 2005, vol. 45, p. 1701-1707.

KRAMARIČ, Petra, PAVLICA, Zlatko, KOKLIČ, Tilen, NEMEC, Alenka, KOŽUH ERŽEN, Nevenka, ŠENTJURC, Marjeta.
Membrane switch hypothesis. 2., Domain structure of phagocytes in horses with recurrent airway obstruction.
J. chem. inf. mod., 2005, vol. 45, p. 1708-1715.

Book chapters

Interaction of alkylphospholipid formulations with breast cancer cells in the context of anticancer drug development.
In: GUNDUZ, Mehmet (ed.), GUNDUZ, Esra (ed.). Breast cancer - focusing tumor microenvironment, stem cells and metastasis.. Rijeka: InTech, 2011, p. 361-384.

All publications

A complete list is available here

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