Ongoing projects

Microspectroscopy-based optimization of the effects of laser pulses on the retina

The most dangerous complication of retinal diseases - the growth of abnormal blood vessels - is currently treated using repeated unpleasant and risky injections of drugs based on antivascular endothelial growth factors directly into the eye. Less commonly, laser surgery is used, which often causes damage to the surrounding healthy tissue. Such damage can be avoided by more accurate laser pulse positioning and by continuously monitoring its impact on the retina.
To achieve this, we will devise a novel principle of detecting the state of the retina using multi-modal imaging and analysis of autofluorescence in real time. Together with better control over the light beam, this new principle will be used in a new generation of ophthalmic therapeutic devices

This project has received funding from the Slovenian research agency under grant No. L7-7561.

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Smart tools for gauging nano hazards

A definitive conclusion about the dangers associated with human or animal exposure to a particular nanomaterial can currently be made upon complex and costly procedures including complete NM characterisation with consequent careful and well-controlled in vivo experiments. To achieve a significant progress in nanotoxicity prediction, we will use in-vivo, in-vitro and in-silico research, combined with systems biology and statistical methods to address main respiratory toxicity pathways for a representative set of nanomaterials, identify the mechanistic key events of the pathways, and relate them to interactions at the bio-nano interface.
Using this knowledge, economic and straightforward tests will be developed to assess the ability of nanomaterial to produce the pathway-relevant key events.This approach will allow us to group materials based on their nanotoxicity and identify properties of concern for new materials, as well as reduce the need for expensive nanotoxicity testing in the future.

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 686098

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